Recently, Shandong Tianli Pharmaceutical's R&D department successfully developed solid sorbitol granules and direct pressure grade mannitol granules through independent research and development, becoming the first domestic enterprise to master the core production technology of direct pressure grade mannitol granules.
The production of tablets is divided into wet granulation compression, dry granulation compression powder direct compression. Due to the short process route, low investment and low labor cost of the powder direct compression, it is extremely competitive in the market. 2/3 of the formulation companies in the United States choose the powder direct compression , and 1/3 the European companies choose the powder direct compression. the high cost of imported direct compression auxiliary materials in China, only 1/10 of the enterprises adopt powder direct compression. Tianli Pharmaceutical started the research and development of direct pressure grade mannitol granule production technology in 2012. It has hired many domestic and foreign technical experts, but it has not been able to break through the technical bottleneck. In July 2020, the R&D department adjusted its thinking, analyzed and studied more than 1,000 domestic and foreign patent materials, investigated more than 100 dry granulation equipment manufacturers, and sent samples for multiple tests. In October, solid sorbitol particles were produced, and the relevant indicators reached the French Roquette sorbitol standards; in November, mannitol direct pressure particles made a breakthrough, and the microscopic morphology and performance indicators of the trial-produced mannitol particles were consistent with Roquette’s sorbitol standards. The special products are consistent.
At present, Tianli Pharmaceutical can produce 700,000 tons of sorbitol every year, ranking first in the world. The successful development of the solid sorbitol process can further expand the product market and increase the added value of the product. The production capacity of mannitol raw powder is currently 20,000 tons/year, accounting for 40% of the domestic market share. The price of direct pressure grade mannitol granules is as high as ￥60/kg, which is twice that of mannitol raw powder. The successful development of the production technology of direct pressure grade mannitol granules will greatly improve the profit margin and market competitiveness of Tianli Pharmaceutical's mannitol. .