Spironolactone CAS 52-01-7

Spironolactone CAS 52-01-7

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Product Details

 

Product name:
Spironolactone
Molecular Formula: 
C24H32O4S
Molecular Structure:
mtxx208
Molecular Weight:
416.6
CAS No.: 
52-01-7


Description

Spironolactone is a white or yellowish-white powder. It is practically insoluble in water, soluble in ethanol (96 per cent). It shows polymorphism.

 

Application

Spironolactone is a synthetic steroid compound, an inefficient diuretic. Applicable to:

1) Edematic diseases: combined with other diuretics to treat congestive heart failure, cirrhosis ascites, renal edema and other edema diseases.

2) Hypertension: as an adjuvant therapy for hypertension

3) Primary aldosteronism

4) Prevention of hypokalemia

 

Specification

Appearance
White or yellowish-white powder.
Specific optical rotation
− 41° to − 46°
Chromium
≤50 ppm
Loss on drying
≤0.5%
Sulfated ash 
≤0.1%
Free thiol compounds     
A blue colour develops.
Related substances:

Δ20-spironolactone
≤0.2%
Aldone
≤0.2%
Disulfanyl-spironolactone
≤0.15%
7β-spironolactone
≤0.3%
Canrenone
≤0.3%
S-[17α-(ethoxymethyl)-17-hydroxy-3-oxoandrost-4-en-7α-yl] ethanethioate ≤0.5%
≤0.5%
Unspecified impurities
≤0.10%
Total impurities
≤0.7%
Assay 
97.5%-102.0%


Packing and Storage

Preserve in well-closed containers.

 

Minimum Order

One package

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