| Product name: | Methyldopa |
| Molecular Formula: | C10H13NO4 |
| Molecular Structure: |  |
| Molecular Weight: | 211.214 |
| CAS No.: | 555-30-6 |
Description
Methyldopa is a white to yellowish-white, fine powder. It is soluble in dilute hydrochloric acid, the solubility in water at 25 ° C is about 10 mg / ml, the pH of the saturated aqueous solution is about 5. I t is slightly soluble in ethanol, insoluble in ether and chloroform.
Application
Methyldopa is an α2-receptor agonistic cardiovascular drug. This product produces metabolite α-methylnorepinephrine in the body, which blocks central α receptors, thereby inhibiting the sympathetic impulse output of heart, kidney and peripheral blood vessels, at the same time, peripheral vascular resistance and plasma renin activity are also reduced, and blood pressure is therefore reduced. It can be used to treat hypertension, including hypertension in kidney disease. It is the first choice for the treatment of hypertension during pregnancy.
Specification
| Appearance | White to yellowish-white, fine powder. |
| Identification A | Infrared absorption: The sample comparing with the spectrum obtained with standard. |
| Identification B | HPLC: The retention time of the major peak the sample solution corresponds to that of the standard solution, as obtained in the Assay. |
| Specific rotation | -25°~-28° |
| Acidity (0.N NaOH) | ≤0.50ml/g |
| Water | 10.0~13.0% |
| Residue on ignition | ≤0.1% |
| Related compounds: | |
| 3-O-Methylmethyldopa | ≤0.15% |
| Impurity B | ≤0.15% |
| Impurity C | ≤0.15% |
| unspecified impurity | ≤0.05% |
| Total impurities | ≤0.5% |
| Residual solvents: | |
| Methanol | ≤3000ppm |
| Dichloromethane | ≤600ppm |
| Benzene | ≤2ppm |
| Toluene | ≤890ppm |
| Assay（on dried basis） | 98.0%～102.0% |
Packing
25kg/drum or as customer’s requirements.
Storage
Preserve in well-closed container.
Minimum Order
One package
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