Methyldopa CAS 555-30-6

Methyldopa CAS 555-30-6

Methyldopa is an antihypertensive drug used for moderate to severe hypertension, as well as sedation and lower intraocular pressure. Especially suitable for renal hypertension and hypertension with decreased renal function.
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Product Details

 

Product name: 
Methyldopa
Molecular Formula:
C10H13NO4
Molecular Structure:
mtxx64
Molecular Weight:
211.214
CAS No.: 555-30-6

          

Description

Methyldopa is a white to yellowish-white, fine powder. It is soluble in dilute hydrochloric acid, the solubility in water at 25 ° C is about 10 mg / ml, the pH of the saturated aqueous solution is about 5. I t is slightly soluble in ethanol, insoluble in ether and chloroform.

 

Application

Methyldopa is an α2-receptor agonistic cardiovascular drug. This product produces metabolite α-methylnorepinephrine in the body, which blocks central α receptors, thereby inhibiting the sympathetic impulse output of heart, kidney and peripheral blood vessels, at the same time, peripheral vascular resistance and plasma renin activity are also reduced, and blood pressure is therefore reduced. It can be used to treat hypertension, including hypertension in kidney disease. It is the first choice for the treatment of hypertension during pregnancy.

 

Specification

Appearance 
White to yellowish-white, fine powder.
Identification A 

Infrared absorption: The sample comparing with the spectrum obtained with standard.

Identification B 

HPLC: The retention time of the major peak the sample solution corresponds to that of the standard solution, as obtained in the Assay.

Specific rotation
-25°~-28°
Acidity (0.N NaOH)
≤0.50ml/g
Water
10.0~13.0%
Residue on ignition
≤0.1%
Related compounds:

3-O-Methylmethyldopa
≤0.15%
Impurity B
≤0.15%
Impurity C   
≤0.15%
unspecified impurity
≤0.05%
Total impurities
≤0.5%
Residual solvents:

Methanol
≤3000ppm
Dichloromethane
≤600ppm
Benzene
≤2ppm
Toluene
≤890ppm
Assay(on dried basis)

98.0%~102.0%

   

Packing

25kg/drum or as customer’s requirements.

 

Storage

Preserve in well-closed container.

 

Minimum Order

One package

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