| Product name: | Clozapine |
| Molecular Formula: | C18H19ClN4 |
| Molecular Structure: |  |
| Molecular Weight: | 326.823 |
| CAS No.: | 5786-21-0 |
Description
Clozapine is a yellow crystalline powder. It is soluble in chloroform, in acetone, and in alcohol; sparingly soluble in acetonitrile; insoluble in water.
Application
Clozapine is an antipsychotic used to treat schizophrenia. Clozapine is a potent antagonist of dopamine and many other receptors, with a Ki value of 9.5 nM in combination with the M1 receptor.
Specification
| Appearance | Yellow crystalline powder. |
| Identification A | Infrared absorption: The IR spectrum of sample, exhibits maxima only at the same wavelength as that a similar preparation of USP |
| Identification B | Retention time by HPLC: The retention time of the major peak in the chromatogram of the Test solution corresponds to the major peak in the chromatogram of the Resolution solution. |
| Melting range | 182℃~186℃ |
| Loss on drying | ≤0.5% |
| Residue on ignition | ≤0.1% |
| Heavy metal | ≤0.002% |
| Related compounds: | |
| Impurity A | ≤0.1% |
| Impurity B | ≤0.2% |
| Impurity C | ≤0.3% |
| Individual unspecified impurity | ≤0.10% |
| Total impurities | ≤0.6% |
| Residual solvents: | |
| Ethanol | ≤1000ppm |
| Toluene | ≤100ppm |
| N,N-Dimethylformamide | ≤880ppm |
| Assay（on dried basis） | 98.0%～102.0% |
| Particle Size | 90% pass 250um |
| Bulk Density | 0.45-0.65g/ml |
| Tapped Density | 0.80-1.00g/ml |
Packing
25kg/drum or as customer’s requirements.
Storage
Preserve in well-closed container.
Minimum Order
One package
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