Clozapine CAS 5786-21-0

Clozapine CAS 5786-21-0

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Product Details

 

Product name: 
Clozapine
Molecular Formula:
C18H19ClN4 
Molecular Structure:  
mtxx62
Molecular Weight:
326.823
CAS No.:  
5786-21-0


Description

Clozapine is a yellow crystalline powder. It is soluble in chloroform, in acetone, and in alcohol; sparingly soluble in acetonitrile; insoluble in water.

 

Application

Clozapine is an antipsychotic used to treat schizophrenia. Clozapine is a potent antagonist of dopamine and many other receptors, with a Ki value of 9.5 nM in combination with the M1 receptor.

 

Specification

Appearance
Yellow crystalline powder.
Identification A
Infrared absorption: The IR spectrum of sample, exhibits maxima only at the same wavelength as that a similar preparation of USP
Identification B

Retention time by HPLC: The retention time of the major peak in the chromatogram of the Test solution corresponds to the major peak in the chromatogram of the Resolution solution.

Melting range
182℃~186℃
Loss on drying
≤0.5%
Residue on ignition

≤0.1%

Heavy metal
≤0.002%
Related compounds:

Impurity A
≤0.1%
Impurity B 
≤0.2%
Impurity C
≤0.3%
Individual unspecified impurity
≤0.10%
Total impurities 
≤0.6%
Residual solvents:

Ethanol
≤1000ppm
Toluene 
≤100ppm
N,N-Dimethylformamide
≤880ppm
Assay(on dried basis)
98.0%~102.0%
Particle Size
90% pass 250um
Bulk Density
0.45-0.65g/ml
Tapped Density
0.80-1.00g/ml

 

Packing

25kg/drum or as customer’s requirements.

 

Storage

Preserve in well-closed container.

 

Minimum Order

One package

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