Hydroxypropyl-β-cyclodextrin (HP-β-CD) CAS 128446-35-5; 94035-02-6; 136019-12-0

Hydroxypropyl-β-cyclodextrin (HP-β-CD) CAS 128446-35-5; 94035-02-6; 136019-12-0

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Product Details


Product name:            Hydroxypropyl-β-cyclodextrin

                                      (HP-β-CD, Hydroxypropyl Betadex, 2-hydroxypropyl-beta-cyclodextirn)

CAS No.:                         128446-35-5; 94035-02-6; 136019-12-0

EINECS:                          420-920-1

Abbreviation:                HPBCD

Molecular formula:     C42H70-nO35(C3H8O2)n

Molecular weight:       1134.98+58n

Qaulity                       Pharma grade / Food grade / Cosmetics grade / Technical grade

Use:                                Medical \ Food \ Chemical \ Cosmetic \ other industries

Molecular Structure:    

Hydroxypropyl-β-cyclodextrin (HP-β-CD)

Description

Hydroxypropyl Betadex is white or off-white amorphous or crystalline powder; odorless, slightly sweet, and highly hygroscopic. This product is very soluble in water, easily soluble in methanol and ethanol, almost insoluble in acetone and chloroform.

Application

Hydroxypropyl-β-cyclodextrin (HP-β-CD) is one of the most widely used cyclodextrin derivatives in current scientific researches and industry applications. It mainly used in food, pharmaceutical and cosmetics industries.

1. In pharmaceuticals industry, HP-β-CD can increase solubility and bioavailability of insoluble drugs, so that the efficacy of drugs can last longer with less ingestion of drugs. It can adjust and control drugs release ratio, decrease side effects of drugs, and enhance stability of drugs. HP-β-CD can be used for oral medication, injection, mucosal delivery systems (including the nasal mucosa, rectum, cornea, etc.), dermal drug delivery systems, lipophilic drugs targeting delivery, and also used as protective agent and stabilizer of protein.

2. In food and perfume industry, HP-β-CD can enhance the stability of nutritional constituent and extend active time of effective constituent. It can cover up bad smell and bad taste of nutritional constituent. It also can improve production processes and product quality.

3. In cosmetics industry, HP-β-CD can reduce stimulate of organic molecular in cosmetic to the skin and mucosa. It can enhance the stability of matter, by preventing oxidation and volatilization of nutrients.

Specification

Standard

USP41/ EP9.6

Appearance

White or almost white, amorphous or   crystalline powder. Freely soluble in water and in propylene glycol.

Identification (IR)

Same absorption   bands as USP Hydroxypropyl Betadex RS

Solubility (in 100cm3 solvent, at 25) :

Water: >180g

Methanol: >33g

DMSO: >33g

Clarity of Solution

Positive

Molar Substitution

0.40~1.50

Betadex

≤1.5%

Propylene Glycol

≤2.5%

Any Other Single Impurity

≤0.25%

Total Impurities Excluding Betadex and   Propylene Glycol

≤1.0%

Propylene Oxide

≤1ppm

Loss on Drying

≤10.0%

Clarity of Solution

1.0g/2ml water solution is   clear and transparent

Conductivity

≤200µS/cm

Bacterial Endotoxins Test

According to preparation needs

The total aerobic microbial count

≤1000cfu/g

The total combined moulds and yeasts count

≤100cfu/g

Packing          

500g/bag , 2kg/bag,  10kg/drum.

Storage  

Preserve in well-closed containers. Store at room temperature.


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