Product name: Hydroxypropyl-β-cyclodextrin
(HP-β-CD, Hydroxypropyl Betadex, 2-hydroxypropyl-beta-cyclodextirn)
CAS No.: 128446-35-5; 94035-02-6; 136019-12-0
EINECS: 420-920-1
Abbreviation: HPBCD
Molecular formula: C42H70-nO35(C3H8O2)n
Molecular weight: 1134.98+58n
Qaulity： Pharma grade / Food grade / Cosmetics grade / Technical grade
Use: Medical \ Food \ Chemical \ Cosmetic \ other industries
Molecular Structure:
Description
Hydroxypropyl Betadex is white or off-white amorphous or crystalline powder; odorless, slightly sweet, and highly hygroscopic. This product is very soluble in water, easily soluble in methanol and ethanol, almost insoluble in acetone and chloroform.
Application
Hydroxypropyl-β-cyclodextrin (HP-β-CD) is one of the most widely used cyclodextrin derivatives in current scientific researches and industry applications. It mainly used in food, pharmaceutical and cosmetics industries.
1. In pharmaceuticals industry, HP-β-CD can increase solubility and bioavailability of insoluble drugs, so that the efficacy of drugs can last longer with less ingestion of drugs. It can adjust and control drugs release ratio, decrease side effects of drugs, and enhance stability of drugs. HP-β-CD can be used for oral medication, injection, mucosal delivery systems (including the nasal mucosa, rectum, cornea, etc.), dermal drug delivery systems, lipophilic drugs targeting delivery, and also used as protective agent and stabilizer of protein.
2. In food and perfume industry, HP-β-CD can enhance the stability of nutritional constituent and extend active time of effective constituent. It can cover up bad smell and bad taste of nutritional constituent. It also can improve production processes and product quality.
3. In cosmetics industry, HP-β-CD can reduce stimulate of organic molecular in cosmetic to the skin and mucosa. It can enhance the stability of matter, by preventing oxidation and volatilization of nutrients.
Specification
Standard | USP41/ EP9.6 |
Appearance | White or almost white, amorphous or crystalline powder. Freely soluble in water and in propylene glycol. |
Identification (IR) | Same absorption bands as USP Hydroxypropyl Betadex RS |
Solubility (in 100cm3 solvent, at 25℃) : | Water: >180g Methanol: >33g DMSO: >33g |
Clarity of Solution | Positive |
Molar Substitution | 0.40~1.50 |
Betadex | ≤1.5% |
Propylene Glycol | ≤2.5% |
Any Other Single Impurity | ≤0.25% |
Total Impurities Excluding Betadex and Propylene Glycol | ≤1.0% |
Propylene Oxide | ≤1ppm |
Loss on Drying | ≤10.0% |
Clarity of Solution | 1.0g/2ml water solution is clear and transparent |
Conductivity | ≤200µS/cm |
Bacterial Endotoxins Test | According to preparation needs |
The total aerobic microbial count | ≤1000cfu/g |
The total combined moulds and yeasts count | ≤100cfu/g |
Packing
500g/bag , 2kg/bag, 10kg/drum.
Storage
Preserve in well-closed containers. Store at room temperature.
