Hydroxypropyl-β-cyclodextrin (HP-β-CD) CAS 128446-35-5; 94035-02-6; 136019-12-0

Hydroxypropyl-β-cyclodextrin (HP-β-CD) CAS 128446-35-5; 94035-02-6; 136019-12-0

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Product Details

Product name:            Hydroxypropyl-β-cyclodextrin

                                      (HP-β-CD, Hydroxypropyl Betadex, 2-hydroxypropyl-beta-cyclodextirn)

CAS No.:                         128446-35-5; 94035-02-6; 136019-12-0

EINECS:                          420-920-1

Abbreviation:                HPBCD

Molecular formula:     C42H70-nO35(C3H8O2)n

Molecular weight:       1134.98+58n

Qaulity                       Pharma grade / Food grade / Cosmetics grade / Technical grade

Use:                                Medical \ Food \ Chemical \ Cosmetic \ other industries

Molecular Structure:    

Hydroxypropyl-β-cyclodextrin (HP-β-CD)


Hydroxypropyl Betadex is white or off-white amorphous or crystalline powder; odorless, slightly sweet, and highly hygroscopic. This product is very soluble in water, easily soluble in methanol and ethanol, almost insoluble in acetone and chloroform.


Hydroxypropyl-β-cyclodextrin (HP-β-CD) is one of the most widely used cyclodextrin derivatives in current scientific researches and industry applications. It mainly used in food, pharmaceutical and cosmetics industries.

1. In pharmaceuticals industry, HP-β-CD can increase solubility and bioavailability of insoluble drugs, so that the efficacy of drugs can last longer with less ingestion of drugs. It can adjust and control drugs release ratio, decrease side effects of drugs, and enhance stability of drugs. HP-β-CD can be used for oral medication, injection, mucosal delivery systems (including the nasal mucosa, rectum, cornea, etc.), dermal drug delivery systems, lipophilic drugs targeting delivery, and also used as protective agent and stabilizer of protein.

2. In food and perfume industry, HP-β-CD can enhance the stability of nutritional constituent and extend active time of effective constituent. It can cover up bad smell and bad taste of nutritional constituent. It also can improve production processes and product quality.

3. In cosmetics industry, HP-β-CD can reduce stimulate of organic molecular in cosmetic to the skin and mucosa. It can enhance the stability of matter, by preventing oxidation and volatilization of nutrients.



USP41/ EP9.6


White or almost white, amorphous or   crystalline powder. Freely soluble in water and in propylene glycol.

Identification (IR)

Same absorption   bands as USP Hydroxypropyl Betadex RS

Solubility (in 100cm3 solvent, at 25) :

Water: >180g

Methanol: >33g

DMSO: >33g

Clarity of Solution


Molar Substitution




Propylene Glycol


Any Other Single Impurity


Total Impurities Excluding Betadex and   Propylene Glycol


Propylene Oxide


Loss on Drying


Clarity of Solution

1.0g/2ml water solution is   clear and transparent



Bacterial Endotoxins Test

According to preparation needs

The total aerobic microbial count


The total combined moulds and yeasts count



500g/bag , 2kg/bag,  10kg/drum.


Preserve in well-closed containers. Store at room temperature.

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