| Product name: | Captopril |
| Molecular Formula: | C9H15NO3S |
| Molecular Structure: |  |
| Molecular Weight: | 217.3 |
| CAS No.: | 62571-86-2 |
Description
Captopril is a white or almost white, crystalline powder. It is soluble in water, freely soluble in methanol and in methylene chloride. It dissolves in dilute solutions of alkali hydroxides.
Application
Captopril is used in the treatment of various types of hypertension, especially in the treatment of intractable hypertension that is ineffective against other antihypertensive drugs. Also used for acute and chronic congestive heart failure, better combined with cardiotonic or diuretic.
Specification
| Appearance | White or almost white, crystalline powder. |
| Appearance of solution | Meets the requirements. |
| PH | 2.0 - 2.6 |
| Specific optical rotation | −127° to −132° |
| epi-captopril | ≤0.2% |
| Heavy metals | ≤20 ppm |
| Loss on drying | ≤1.0% |
| Sulfated ash | ≤0.2% |
| Related substances: | |
| Captopril disulfide | ≤1.0% |
| (2S)-1-[(2S)-3-bromo-2-methylpropanoyl]-pyrrolidine-2-carboxylic acid | ≤0.15% |
| (2S)-1-(2-methylpropanoyl)pyrrolidine-2-carboxylic acid | ≤0.15% |
| (2RS)-2-methyl-3-sulfanylpropanoic acid | ≤0.15% |
| (2RS)-3-bromo-2-methylpropanoic acid | ≤0.15% |
| Acetylcaptopril | ≤0.2% |
| Unspecified impurities | ≤0.10% |
| Total impuritie | ≤1.2% |
| Assay | 98.0%-101.5% |
Packing and Storage
Preserve in tight container.
Minimum Order
One package
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