Product name: | Calcium Folinate |
Molecular Formula: | C20H21CaN7O7,xH2O |
Molecular Structure: | ![]() |
Molecular Weight: | 511.5 |
CAS No.: | 1492-18-8 |
Description
Calcium folinate is a white or light yellow, amorphous or crystalline, hygroscopic powder. It is sparingly soluble in water, practically insoluble in acetone and in ethanol (96 per cent). The amorphous form may produce supersaturated solutions in water.
Application
Calcium folinate is mainly used as an antidote to folic acid antagonists such as methotrexate, pyrimethamine or trimethoprim. Also used for megaloblastic anemia caused by folic acid deficiency. When used in combination with fluorouracil, it is used to treat advanced colon cancer and rectal cancer.
Specification
Appearance | White or light yellow, amorphous or crystalline, hygroscopic powder. |
Appearance of solution | Meets the requirements. |
PH | 6.8 - 8.0 |
Specific optical rotation | + 14.4° to + 18.0° |
Acetone | ≤0.5% |
Ethanol | ≤3.0% |
Methanol | ≤0.5% |
Chlorides | ≤0.5% |
Heavy metals | ≤50 ppm |
Platinum | ≤20 ppm |
Water | ≤17.0% |
Bacterial endotoxins | ≤0.5 IU/mg |
Related substances: | |
Impurity D | ≤1% |
Each impurity (impurities A, B, C, E, F, G) | ≤1% |
Sum of impurities other than D | ≤2.5% |
Assay | 97.0%-102.0% |
Packing and Storage
Preserve in an airtight container, protected from light. If the substance is sterile, store in a sterile, airtight, tamper-proof container.
Minimum Order
One package