Calcium Folinate CAS 1492-18-8

Calcium Folinate CAS 1492-18-8

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Product Details

 

Product name: 
Calcium Folinate
Molecular Formula: 
C20H21CaN7O7,xH2O
Molecular Structure:
mtxx74
Molecular Weight
511.5
CAS No.:
1492-18-8


Description

Calcium folinate is a white or light yellow, amorphous or crystalline, hygroscopic powder. It is sparingly soluble in water, practically insoluble in acetone and in ethanol (96 per cent). The amorphous form may produce supersaturated solutions in water.

 

Application

Calcium folinate is mainly used as an antidote to folic acid antagonists such as methotrexate, pyrimethamine or trimethoprim. Also used for megaloblastic anemia caused by folic acid deficiency. When used in combination with fluorouracil, it is used to treat advanced colon cancer and rectal cancer.

 

Specification

Appearance
White or light yellow, amorphous or crystalline, hygroscopic powder.
Appearance of solution
Meets the requirements.
PH 
6.8 - 8.0
Specific optical rotation
+ 14.4° to + 18.0°
Acetone
≤0.5%
Ethanol
≤3.0%
Methanol
≤0.5%
Chlorides
≤0.5%
Heavy metals
≤50 ppm
Platinum
≤20 ppm
Water
≤17.0%
Bacterial endotoxins
≤0.5 IU/mg
Related substances:

Impurity D
≤1%
Each impurity (impurities A, B, C, E, F, G) 
≤1%
Sum of impurities other than D
≤2.5%
Assay
97.0%-102.0%


Packing and Storage

Preserve in an airtight container, protected from light. If the substance is sterile, store in a sterile, airtight, tamper-proof container.

 

Minimum Order

One package

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