Methotrexate CAS 59-05-2

Methotrexate CAS 59-05-2

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Product Details

 

Product name: 
Methotrexate
Molecular Formula:
C20H22N8O5
Molecular Structure:
mtxx30
Molecular Weight:
454.4
CAS No.:
59-05-2


Description

Methotrexate is an antimetabolite used in the treatment of certain neoplastic diseases, severe psoriasis, and adult rheumatoid arthritis. It is practically insoluble in water, in ethanol (96 per cent) and in methylene chloride. It dissolves in dilute mineral acids and in dilute solutions of alkali hydroxides and carbonates.

 

Application

Methotrexate is an antifolate anticancer drug. It is clinically used for acute leukemia, especially acute lymphocytic leukemia, chorionic epithelial cancer and malignant mole. It has certain curative effect on head and neck cancer, breast cancer, lung cancer and pelvic tumor.

 

Specification

Appearance
Yellow or orange, crystalline, hygroscopic powder.
Heavy metals 
≤50 ppm
Water
≤13.0%
Sulfated ash 
≤0.1%
Related substances:

4-aminofolic acid   
≤0.3%
N-methylfolic acid
≤0.5%
4-amino-N10-methylpteroic acid
≤0.3%
(R)-methotrexate
≤3.0%
methotrexate 5-methyl ester
≤0.2%
methotrexate 1-methyl ester 
≤0.2%
Unspecified impurities
≤0.05%
Sum of impurities other than B, C and E 
≤0.5%
Assay
97.0%-102.0%


Packing and Storage

Preserve in tight, light-resistant containers.

 

Minimum Order

One package

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