| Product name: | Doxycycline Hyclate |
| Molecular Formula： | C22H24N2O8,HCI,½C2H6O,½H2O |
| Molecular Structure： |  |
| Molecular Weight： | 512.9 |
| CAS No.: | 24390-14-5 |
Description
Doxycycline hyclate is a yellow, hygroscopic, crystalline powder. It is freely soluble in water and in methanol, sparingly soluble in ethanol (96 per cent). It dissolves in solutions of alkali hydroxides and carbonates.
Application
Doxycycline hydrochloride is a tetracycline antibiotic. This product is a broad-spectrum bacteriostatic agent, with bactericidal effect at high concentrations. Many rickettsia, mycoplasma, chlamydia, atypical mycobacteria, and spirochetes are all sensitive to it. It has better effects on gram-positive bacteria than gram-negative bacteria, but Enterococcus is resistant to it. Others such as Actinomyces, Bacillus anthracis, Listeria monocytogenes, Clostridium, Nocardia, Vibrio, Brucella, Campylobacter, Yersinia are sensitive to it. This product has certain antibacterial activity against Neisseria gonorrhoeae, but the penicillin-resistant Neisseria gonorrhoeae is also resistant to doxycycline. Due to the wide application of tetracyclines, common clinical pathogens are highly resistant to this product, including gram-positive bacteria such as staphylococci and most gram-negative bacilli. There is cross-resistance between this product and different varieties of tetracycline antibiotics.
Specification
| Appearance | Yellow, hygroscopic, crystalline powder. |
| PH | 2.0 - 3.0 |
| Specific optical rotation | -120° to -105° |
| Specific absorbance | 300 - 335 |
| Light-absorbing impurities | Meets the requirements. |
| Ethanol | 4.3% - 6.0% |
| Heavy metals | ≤50 ppm |
| Water | 1.4% - 2.8% |
| Sulfated ash | ≤0.4% |
| Bacterial endotoxins | ≤1.14 IU/mg |
| Related substances: | |
| 6-epidoxycycline | ≤2.0% |
| Metacycline | ≤2.0% |
| 4-epidoxycycline | ≤0.5% |
| 4-epi-6-epidoxycycline | ≤0.5% |
| oxytetracycline | ≤0.5% |
( 4S,4aR,5S,5aR,6R,12aS)-2-acetyl-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-4a, 5a,6,12atetrahydrotetracene-1,11(4H,5H)-dione (2-acetyl-2- decarbamoyldoxycycline) | ≤0.5% |
| Any other impurity | ≤0.5% |
| Assay | 95.0%-102.0% |
Packing and Storage
Preserve in an airtight container, protected from light. If the substance is sterile, store in a sterile, airtight, tamper-proof container.
Minimum Order
One package
