Doxycycline Hyclate CAS 24390-14-5

Doxycycline Hyclate CAS 24390-14-5

Doxycycline hyclate is a tetracycline antibiotic. It is mainly used for upper respiratory tract infection, tonsillitis, biliary tract infection, lymphadenitis, cellulitis, senile chronic bronchitis caused by sensitive gram-positive cocci and gram-negative bacilli. It is also used for typhus, tsutsugamushi disease and Mycoplasma pneumonia. It can also be used to treat cholera and to prevent falciparum malaria and Leptospira infection.
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Product Details


Product name:  
Doxycycline Hyclate
Molecular Formula
C22H24N2O8,HCI,½C2H6O,½H2O
Molecular Structure
mtxx07
Molecular Weight
512.9
CAS No.:  
24390-14-5


Description

Doxycycline hyclate is a yellow, hygroscopic, crystalline powder. It is freely soluble in water and in methanol, sparingly soluble in ethanol (96 per cent). It dissolves in solutions of alkali hydroxides and carbonates.

 

Application

Doxycycline hydrochloride is a tetracycline antibiotic. This product is a broad-spectrum bacteriostatic agent, with bactericidal effect at high concentrations. Many rickettsia, mycoplasma, chlamydia, atypical mycobacteria, and spirochetes are all sensitive to it. It has better effects on gram-positive bacteria than gram-negative bacteria, but Enterococcus is resistant to it. Others such as Actinomyces, Bacillus anthracis, Listeria monocytogenes, Clostridium, Nocardia, Vibrio, Brucella, Campylobacter, Yersinia are sensitive to it. This product has certain antibacterial activity against Neisseria gonorrhoeae, but the penicillin-resistant Neisseria gonorrhoeae is also resistant to doxycycline. Due to the wide application of tetracyclines, common clinical pathogens are highly resistant to this product, including gram-positive bacteria such as staphylococci and most gram-negative bacilli. There is cross-resistance between this product and different varieties of tetracycline antibiotics.

 

Specification

Appearance
Yellow, hygroscopic, crystalline powder.
PH
2.0 - 3.0
Specific optical rotation
-120° to -105°
Specific absorbance
300 - 335
Light-absorbing impurities
Meets the requirements.
Ethanol   
4.3% - 6.0%
Heavy metals
≤50 ppm 
Water   
1.4% - 2.8%
Sulfated ash
≤0.4%
Bacterial endotoxins
≤1.14 IU/mg
Related substances:

6-epidoxycycline
≤2.0%
Metacycline
≤2.0%
4-epidoxycycline
≤0.5%
4-epi-6-epidoxycycline
≤0.5%
oxytetracycline
≤0.5%

( 4S,4aR,5S,5aR,6R,12aS)-2-acetyl-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-4a,

5a,6,12atetrahydrotetracene-1,11(4H,5H)-dione (2-acetyl-2- decarbamoyldoxycycline)              

≤0.5%
Any other impurity
≤0.5%
Assay

95.0%-102.0%

        

Packing and Storage

Preserve in an airtight container, protected from light. If the substance is sterile, store in a sterile, airtight, tamper-proof container.

 

Minimum Order

One package

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