| Product name: | Doxycycline Hyclate |
| Molecular Formula： | C22H24N2O8,HCI,½C2H6O,½H2O |
| Molecular Structure： |  |
| Molecular Weight： | 512.9 |
| CAS No.: | 24390-14-5 |
Description
Doxycycline hyclate is a yellow, hygroscopic, crystalline powder. It is freely soluble in water and in methanol, sparingly soluble in ethanol (96 per cent). It dissolves in solutions of alkali hydroxides and carbonates.
Application
Doxycycline hyclate is a tetracycline antibiotic. It is mainly used for upper respiratory tract infection, tonsillitis, biliary tract infection, lymphadenitis, cellulitis, senile chronic bronchitis caused by sensitive gram-positive cocci and gram-negative bacilli. It is also used for typhus, tsutsugamushi disease and Mycoplasma pneumonia. It can also be used to treat cholera and to prevent falciparum malaria and Leptospira infection.
Specification
| Appearance | Yellow, hygroscopic, crystalline powder. |
| PH | 2.0 - 3.0 |
| Specific optical rotation | -120° to -105° |
| Specific absorbance | 300 - 335 |
| Light-absorbing impurities | Meets the requirements. |
| Ethanol | 4.3% - 6.0% |
| Heavy metals | ≤50 ppm |
| Water | 1.4% - 2.8% |
| Sulfated ash | ≤0.4% |
| Bacterial endotoxins | ≤1.14 IU/mg |
| Related substances: | |
| 6-epidoxycycline | ≤2.0% |
| Metacycline | ≤2.0% |
| 4-epidoxycycline | ≤0.5% |
| 4-epi-6-epidoxycycline | ≤0.5% |
| oxytetracycline | ≤0.5% |
( 4S,4aR,5S,5aR,6R,12aS)-2-acetyl-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-4a, 5a,6,12atetrahydrotetracene-1,11(4H,5H)-dione (2-acetyl-2- decarbamoyldoxycycline) | ≤0.5% |
| Any other impurity | ≤0.5% |
| Assay | 95.0%-102.0% |
Packing and Storage
Preserve in an airtight container, protected from light. If the substance is sterile, store in a sterile, airtight, tamper-proof container.
Minimum Order
One package
