Product name: Chlortetracycline HCL
Specification： EP10.0
Molecular Formula: C22H24Cl2N2O8
Molecular Structure:
Molecular Weight: 515.341
CAS No.: 64-72-2
Description
Chlortetracycline hydrochloride is golden yellow or yellow crystals, odorless, and the color gradually darkens when exposed to light, slightly soluble in water or ethanol, almost insoluble in acetone or ether.
Application
Chlortetracycline is obtained from the culture solution of Streptomyces aureofaciens. Commonly used hydrochloride, its aqueous solution is the most unstable among tetracyclines, and is quickly destroyed in neutral or alkaline solutions. The antibacterial effect is the same as that of oxytetracycline. It is not used for systemic infections because of its strong irritation. It is mostly used as a raw material for external preparations and feed drug additives. Chlortetracycline hydrochloride ointment can prevent and treat superficial eye infections caused by tetracycline-sensitive bacteria.
It has a strong inhibitory effect on Gram-positive and negative bacteria, Chlamydia, Mycoplasma (Mycoplasma), and Rickettsia.
It is suitable for chicken pullorum, typhoid fever, swine bacterial enteritis and bacterial diseases of poultry and livestock.
It is used as the raw material of medicine for prevention and treatment of diseases.
Specification
Appearance | Yellow powder |
Identification: | |
A (Current Ph. Eur. 2.2.27) | Thin-Layer Chromatography |
B (Current Ph. Eur. 0173) | The color becomes brownish |
C (Current Ph. Eur. 2.3.1) | It gives reaction (a) of chlorides |
D (Current Ph. Eur. 2.2.29) | Liquid chromatography |
pH (Current Ph. Eur. 2.2.3) | 2.3~3.3 |
Specific Optical Rotation (Current Ph. Eur.2.2.7) | -250°~ -235°(anhydrous substance) |
Absorbance (Current Ph. Eur. 2.2.25) | ≤0.40, 460nm |
Related substances (Current Ph. Eur. 2.2.29) : | |
Impurity A (4-epichlortetracycline) | ≤4.0% |
Impurity B (demeclocycline) | ≤1.0% |
Impurity E (4-epidemethylchlortetracycline) | ≤1.0% |
Impurity J (anhydrotetracycline) | ≤1.0% |
Impurity D (4-epitetracyclie) | ≤0.2% |
Impurity G (isochlortetracycline) | ≤0.2% |
Impurity H (2-acetyl-2-decarboxamidochlortetracycline) | ≤0.2% |
Impurity L (anhydrochlortetracycline) | ≤0.2% |
Impurity K (4-epianhydrochlortetracycline) | ≤0.15% |
Unspecified impurities: | |
Impurity C (4-epidemethyltetracycline) | ≤0.10% |
Impurity F (4-epiisochlortetracycline) | ≤0.10% |
Impurity I (4-epianhydrotetracycline) | ≤0.10% |
Disregard limit (Other unknown) | ≤0.05% |
Sum of impurities other than A | ≤2.0% |
Water (Current Ph. Eur. 2.5.12) | ≤2.0% |
Sulfated ash (Current Ph. Eur. 2.4.14) | ≤0.5% |
Assay (Current Ph. Eur. 2.2.29): | |
Chlortetracycline hydrochloride (CTC. HCl) | ≥89.5% (anhydrous substance) |
Tetracycline hydrochloride (TC. HCl) | ≤6.0% (anhydrous substance) |
CTC.HCl + TC.HCl | 94.5~102.0% (anhydrous substance) |
Ethanol (SOP) | ≤0.5% (GC) |
Packing
25kgs / drum
Storage：
It should be protected from light, sealed and stored in a dry place.
Shelf Life :
48 months from date of production when stored in good condition.
Minimum Order
One package.
