Chlortetracycline HCL CAS 64-72-2

Chlortetracycline HCL CAS 64-72-2

Chlortetracycline hydrochloride is a tetracycline spectrum antibiotic, which has strong inhibitory effect on Gram-positive and Gram-negative bacteria, Chlamydia, Mycoplasma (Mycoplasma), and Rickettsia.
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Product Details

 

Product name:             Chlortetracycline HCL

 

Specification             EP10.0

 

Molecular Formula:      C22H24Cl2N2O8

 

Molecular Structure:    

                                Molecular Structure

                                             

Molecular Weight:         515.341


CAS No.:                         64-72-2


Description

Chlortetracycline hydrochloride is golden yellow or yellow crystals, odorless, and the color gradually darkens when exposed to light, slightly soluble in water or ethanol, almost insoluble in acetone or ether.

 

Application

Chlortetracycline is obtained from the culture solution of Streptomyces aureofaciens. Commonly used hydrochloride, its aqueous solution is the most unstable among tetracyclines, and is quickly destroyed in neutral or alkaline solutions. The antibacterial effect is the same as that of oxytetracycline. It is not used for systemic infections because of its strong irritation. It is mostly used as a raw material for external preparations and feed drug additives. Chlortetracycline hydrochloride ointment can prevent and treat superficial eye infections caused by tetracycline-sensitive bacteria.

  • It has a strong inhibitory effect on Gram-positive and negative bacteria, Chlamydia, Mycoplasma (Mycoplasma), and Rickettsia.

  • It is suitable for chicken pullorum, typhoid fever, swine bacterial enteritis and bacterial diseases of poultry and livestock.

  • It is used as the raw material of medicine for prevention and treatment of diseases.

Specification

Appearance

Yellow powder

Identification:

A (Current Ph. Eur. 2.2.27)

Thin-Layer Chromatography

B (Current Ph. Eur. 0173)

The color becomes brownish

C (Current Ph. Eur. 2.3.1)

It gives reaction (a) of chlorides

D (Current Ph. Eur. 2.2.29)

Liquid chromatography

pH (Current Ph. Eur. 2.2.3)

2.3~3.3

Specific Optical Rotation (Current Ph. Eur.2.2.7)

-250°~   -235°(anhydrous   substance)

Absorbance (Current Ph. Eur. 2.2.25)

≤0.40, 460nm

Related   substances (Current Ph. Eur. 2.2.29) :

Impurity A (4-epichlortetracycline)

≤4.0%

Impurity B (demeclocycline)

≤1.0%

Impurity E (4-epidemethylchlortetracycline)

≤1.0%

Impurity J (anhydrotetracycline)

≤1.0%

Impurity D (4-epitetracyclie)

≤0.2%

Impurity G (isochlortetracycline)

≤0.2%

Impurity H (2-acetyl-2-decarboxamidochlortetracycline)

≤0.2%

Impurity L (anhydrochlortetracycline)

≤0.2%

Impurity K (4-epianhydrochlortetracycline)

≤0.15%

Unspecified   impurities:

Impurity C (4-epidemethyltetracycline)

≤0.10%

Impurity F (4-epiisochlortetracycline)

≤0.10%

Impurity I (4-epianhydrotetracycline)

≤0.10%

Disregard limit (Other unknown)

≤0.05%

Sum of impurities other than A

≤2.0%

Water (Current Ph. Eur. 2.5.12)

≤2.0%

Sulfated ash (Current Ph. Eur. 2.4.14)

≤0.5%

Assay   (Current Ph. Eur. 2.2.29):

Chlortetracycline hydrochloride (CTC. HCl)

≥89.5% (anhydrous substance)

Tetracycline hydrochloride (TC. HCl)

≤6.0% (anhydrous substance)

CTC.HCl + TC.HCl

94.5~102.0% (anhydrous substance)

Ethanol (SOP)

≤0.5% (GC)

 

Packing

25kgs / drum

Storage

It should be protected from light, sealed and stored in a dry place.

Shelf Life :

48 months from date of production when stored in good condition.

Minimum Order

One package.



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