Trimethoprim Water Soluble 30%

Trimethoprim Water Soluble 30%

[Introduction to Drugs] Trimethoprim Water Soluble 30% CAS 738-37-2 is Trimethoprim Phenypropanol Disulfonic acid Sodium (TMP-Na). In terms of dry products, the content of C32H34N4O15S4Na4 should not be less than 98.0%. The product has good water solubility and is alkaline. The compatibility of TMP with sulfanilamide sodium salts is stable, which broadens the compatibility of TMP with sulfanilamide and other alkaline water-soluble drugs.
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Product Details

Trimethoprim Water Soluble 30% CAS 738-37-2 is Trimethoprim Phenypropanol Disulfonic acid Sodium (TMP-Na). In terms of dry products, the content of C32H34N4O15S4Na4 should not be less than 98.0%. The product has good water solubility and is alkaline. The compatibility of TMP with sulfanilamide sodium salts is stable, which broadens the compatibility of TMP with sulfanilamide and other alkaline water-soluble drugs. 


Trimethoprim (TMP for short), as a sulfonamide synergist, can increase the antibacterial effect of sulfonamides by ten to tens of times, and has been widely used in veterinary medicine.


    TMP itself is insoluble in water, and cannot be directly made into soluble powder with sulfa sodium salt, which is inconvenient to use. Trimethoprim Lactate is acidic. Compatibility with alkaline sulfonamide sodium salt will cause TMP precipitation, especially when it is concentrated, the precipitation will be more serious, so that TMP cannot be taken by animals through drinking water, which can not play a synergistic effect and hiddenly increase costs; and Sulfonamide sodium salt compound medicines are prone to agglomeration, discoloration, poor water solubility, etc. due to acid-base reactions, resulting in returns, rework and increased costs.


    The emergence of TMP-Na (alkaline water-soluble TMP) completely solved the above problems

    1. TMP-Na (alkaline water-soluble TMP) is produced by spray drying, with stable properties, pH 8-10, and it is very soluble in water, and it is stable after being compatible with sulfonamide sodium salt.


    2. Compared with TMP in the production of water injection and oral liquid, TMP-Na can save organic solvents and save costs, and the production process is simple, the finished product is stable, the bioavailability is high, and the irritation is small.


    3. In the production of soluble powder, TMP-Na is compared with Trimethoprim Lactate. After being compatible with sulfa sodium salt, the powder state is stable, which solves the problem of yellowing and agglomeration of the finished product; it does not produce turbidity or precipitation after being dissolved in water. The TMP and sulfa sodium salt in the preparation drugs can all be taken by animals, so that TMP can really play a synergistic effect on sulfa drugs.


Product name:      Trimethoprim Water Soluble 30%

Molecular Formula:      C32H34N4O15S4Na4

Molecular Structure:  

TMP-NA

Molecular Weight:    934.84  

CAS No.:                    738-37-2

Description

Trimethoprim Water Soluble 30% is white, off-white or light yellow powder, odorless and bitter. This product is soluble in water and slightly soluble in ethanol.

Application

This product is an antibacterial synergist, used alone for respiratory infections, urinary tract infections, intestinal infections and other diseases. As an antibacterial synergist, it can also treat poultry bacterial infections and coccidiosis. It can be mixed with basic antibacterial drugs such as sulfa drugs to make stable powders and finished products such as water needles, which can increase the antibacterial effect of sulfa drugs by several to dozens of times.

Specification

Identification

Precipitation test

Characters

White or yellowish-white powder

Clarity of Solution

Solution is clear

Alkalinity

pH:8.0-10.0

Loss of drying

≤8.0%

Reside on ignition

≤0.2%

Assay(%)

Not less than 30% (the dried)


Packing          

25Kg per fibre drum

Storage  

Under normal room temperature, away from the direct sunlight.

Supply Availability

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Trimethoprim Water Soluble 30% 1. Good water solubility 2.Alkaline, stable after compatibility with sulfa sodium salt 3. Broadened the use of TMP and basic water-soluble drugs such as sulfa [Properties] This product is white, off-white or light yellow powder; odorless and bitter. This product is soluble in water and slightly soluble in ethanol. [Alkalinity] pH: 8.0-10.0. [Dry weight loss] ≤ 8.0%.

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