Terbinafine Hydrochloride CAS 78628-80-5

Terbinafine Hydrochloride CAS 78628-80-5

Terbinafine hydrochloride is an allylamine drug with broad-spectrum antifungal activity. This product can specifically interfere with the early biosynthesis of fungal ergosterol, highly selectively inhibit fungal squalene epoxidase, and block the squalene epoxidation reaction during the formation of fungal cell membranes, thereby achieving killing or Inhibit the effect of fungi.The effect is similar to bromhexine. It mainly affects the secretion of bronchial glands at the cellular level. It can break the disulfide bond of mucin in the mucus, increase the secretion of low-viscosity sialomucin, and reduce the production of high-viscosity fucomucin. , So that the viscosity of sputum is reduced, which is conducive to sputum discharge. The oral administration takes effect quickly, and the obvious effect can be seen 4 hours after taking. It is widely distributed in lung tissue, and finally excreted in urine in the form of prototype and metabolites.
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Product Details

 

Product name: 
Terbinafine Hydrochloride
Molecular Formula:
C6H8N2O2S
Molecular Structure:
mtxx19
Molecular Weight: 
327.9
CAS No.: 
78628-80-5


Description

Terbinafine hydrochloride is a white or almost white powder. It is very slightly or slightly soluble in water, freely soluble in anhydrous ethanol and in methanol, slightly soluble in acetone.

 

Application

Terbinafine Hydrochloride can treat skin, hair and nail infections caused by Trichophyton, Microsporum canis and Fusarium oxysporum. It can also treat various rickets (body lice, tinea, hand, foot and head lice, etc.) as well as skin yeast infections caused by Candida (Candida albicans, etc.), and hyperthyroidism caused by mold.

 

Specification

Appearance
White or almost white powder.
Loss on drying 
≤0.5%
Sulfated ash
≤0.1%
Related substances:

cis-terbinafine
≤0.15%

(2E,4E)-4-(4,4-dimethylpent-2-yn-1-ylidene)-N,N′-dimethyl-N,N′-bis(naphthalen-1-ylmethyl)pent-2-

ene-1,5-diamine 

≤0.05%
Unspecified impurities
≤0.10%
Total impurities
≤0.3%
Assay
99.0%-101.0%


Packing and Storage

Preserve in well-closed containers, protected from light. Store at room temperature

 

Minimum Order

One package

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